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Article

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18.

The Journal of experimental medicine - 2 Aug 2010

Salcedo Rosalba, Worschech Andrea, Cardone Marco, Jones Yava, Gyulai Zsofia, Dai Ren-Ming, Wang Ena, Ma Winnie, Haines Diana, O'hUigin Colm, Marincola Francesco M, Trinchieri Giorgio

Abstract excerpt

Signaling through the adaptor protein myeloid differentiation factor 88 (MyD88) promotes carcinogenesis in several cancer models. In contrast, MyD88 signaling has a protective role in the development of azoxymethane (AOM)/dextran sodium sulfate (DSS) colitis-associated cancer (CAC). The inability of Myd88(-/-) mice to heal ulcers generated upon injury creates an altered inflammatory environment that induces early...

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Identifiers

PMID: 20624890
DOI: 10.1084/jem.20100199
PMCID: PMC2916129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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