Article
Extracellular ATP Induces Vascular Inflammation and Atherosclerosis via Purinergic Receptor Y2 in Mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2016
Stachon Peter, Geis Serjosha, Peikert Alexander, Heidenreich Adrian, Michel Nathaly Anto, Ünal Fatih, Hoppe Natalie, Dufner Bianca, Schulte Lisa, Marchini Timoteo, Cicko Sanja, Ayata Korcan, Zech Andreas, Wolf Dennis, Hilgendorf Ingo, Willecke Florian, Reinöhl Jochen, von Zur Mühlen Constantin, Bode Christoph, Idzko Marco, Zirlik Andreas
Abstract excerpt
OBJECTIVE: A solid body of evidence supports a role of extracellular ATP and its P2 receptors in innate and adaptive immunity. It promotes inflammation as a danger signal in various chronic inflammatory diseases. Thus, we hypothesize contribution of extracellular ATP and its receptor P2Y2 in vascular inflammation and atherosclerosis. APPROACH AND RESULTS: Extracellular ATP induced leukocyte rolling, adhesion, and...
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