Article
Identification of a potent inverse agonist at a constitutively active mutant of human P2Y12 receptor.
Molecular pharmacology - 1 Jan 2006
Ding Zhongren, Kim Soochong, Kunapuli Satya P
Abstract excerpt
Human platelets express two P2Y receptors: G(q)-coupled P2Y(1), and G(i)-coupled P2Y(12). Both P2Y(1) and P2Y(12) are ADP receptors on human platelets and are essential for ADP-induced platelet aggregation that plays pivotal roles in thrombosis and hemostasis. Numerous constitutively active G protein-coupled receptors have been described in natural or recombinant systems, but in the P2Y receptors, to date, no...
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