Article
Frequency of certain single-nucleotide polymorphisms and duplication of CYP2D6 in the Jordanian population.
Genetic testing and molecular biomarkers - 1 Oct 2012
Zihlif Malek, Imraish Amer, Irshaid Yacoub M
Abstract excerpt
The CYP2D6 isozymes are responsible for metabolism of 7-10% of clinically available drugs. Genetic polymorphism in CYP2D6 may have an impact on drug efficacy and toxicity. The aim of this study was to determine the allelic frequency of CYP2D6*4, *10, and *17 and CYP2D6*2×N duplication allele in 192 healthy unrelated male and female Jordanian volunteers. Polymerase chain reaction (PCR)-restriction fragment length...
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