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Genetic polymorphisms of drug-metabolizing enzymes CYP2D6, CYP2C9, CYP2C19 and CYP3A5 in the Greek population.

Fundamental & clinical pharmacology - 1 Aug 2007

Arvanitidis Kostas, Ragia Georgia, Iordanidou Maria, Kyriaki Sofia, Xanthi Athanasia, Tavridou Anna, Manolopoulos Vangelis G

Abstract excerpt

The aim of the present study was to determine the prevalence of the most common allelic variants of the polymorphic cytochrome P450 (CYP) enzymes CYP2D6, CYP2C9, CYP2C19 and CYP3A5 and to predict the genotype frequency for each polymorphism in the Greek population. DNA isolated from peripheral blood samples derived from 283 non-related Greek ethnic subjects was used to determine the frequency of CYP2D6*3,...

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Identifiers

PMID: 17635181
DOI: 10.1111/j.1472-8206.2007.00510.x

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