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Article

Polynucleotide phosphorylase plays an important role in the generation of spontaneous mutations in Escherichia coli.

Journal of bacteriology - 1 Oct 2012

Becket Elinne, Tse Lawrence, Yung Madeline, Cosico Alexander, Miller Jeffrey H

Abstract excerpt

Polynucleotide phosphorylase (PNP) plays a central role in RNA degradation, generating a pool of ribonucleoside diphosphates (rNDPs) that can be converted to deoxyribonucleoside diphosphates (dNDPs) by ribonucleotide reductase. We report here that spontaneous mutations resulting from replication errors, which are normally repaired by the mismatch repair (MMR) system, are sharply reduced in a PNP-deficient...

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Source

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Identifiers

PMID: 22904280
DOI: 10.1128/JB.00962-12
PMCID: PMC3458659

Genes

PNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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