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Article

Polynucleotide phosphorylase protects Escherichia coli against oxidative stress.

Biochemistry - 10 Mar 2009

Wu Jinhua, Jiang Zhe, Liu Min, Gong Xin, Wu Shaohui, Burns Christopher M, Li Zhongwei

Abstract excerpt

Escherichia coli polynucleotide phosphorylase (PNPase) primarily functions in RNA degradation. It is an exoribonuclease and integral component of the multienzyme RNA degradosome complex [Carpousis et al. (1994) Cell 76, 889]. PNPase was previously shown to specifically bind a synthetic RNA containing the oxidative lesion 8-hydroxyguanine (8-oxoG) [Hayakawa et al. (2001) Biochemistry 40, 9977], suggesting a...

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PMID: 19219992
DOI: 10.1021/bi801752p
PMCID: PMC2697445

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