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Article

Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice.

PloS one - 1 Jan 2012

Bozdagi Ozlem, Sakurai Takeshi, Dorr Nathan, Pilorge Marion, Takahashi Nagahide, Buxbaum Joseph D

Abstract excerpt

BACKGROUND: Copy number variation (CNV) at the 15q11.2 region, which includes a gene that codes for CYFIP1 (cytoplasmic FMR1 interacting protein 1), has been implicated in autism, intellectual disability and additional neuropsychiatric phenotypes. In the current study we studied the function of Cyfip1 in synaptic physiology and behavior, using mice with a disruption of the Cyfip1 gene. METHODOLOGY/PRINCIPAL...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22900020
DOI: 10.1371/journal.pone.0042422
PMCID: PMC3416859

Genes

CYFIP1
FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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