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Converging evidence that sequence variations in the novel candidate gene MAP2K7 (MKK7) are functionally associated with schizophrenia.

Human molecular genetics - 15 Nov 2012

Winchester Catherine L, Ohzeki Hiromitsu, Vouyiouklis Demetrius A, Thompson Rhiannon, Penninger Josef M, Yamagami Keiji, Norrie John D, Hunter Robert, Pratt Judith A, Morris Brian J

Abstract excerpt

Schizophrenia is a debilitating psychiatric disease with a strong genetic contribution, potentially linked to altered glutamatergic function in brain regions such as the prefrontal cortex (PFC). Here, we report converging evidence to support a functional candidate gene for schizophrenia. In post-mortem PFC from patients with schizophrenia, we detected decreased expression of MKK7/MAP2K7-a kinase activated by...

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PMID: 22899651
DOI: 10.1093/hmg/dds331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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