Article
A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia.
Schizophrenia research - 1 Apr 2008
Ohtsuki Tsuyuka, Koga Minori, Ishiguro Hiroki, Horiuchi Yasue, Arai Makoto, Niizato Kazuhiro, Itokawa Masanari, Inada Toshiya, Iwata Nakao, Iritani Shyuji, Ozaki Norio, Kunugi Hiroshi, Ujike Hiroshi, Watanabe Yuichiro, Someya Toshiuki, Arinami Tadao
Abstract excerpt
INTRODUCTION: Glutamate dysfunction has been implicated in the pathophysiology of schizophrenia. The metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors. GRM7, the gene that encodes mGluR7, is expressed in many regions of the human central nervous system. The GRM7 gene is lo...
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