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Article

JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk

28 Jan 2019

Abstract excerpt

BACKGROUND: Important insight into the mechanisms through which gene-environmental interactions cause schizophrenia can be achieved through preclinical studies combining prenatal immune stimuli with disease-related genetic risk modifications. Accumulating evidence associates JNK signalling molecules, including MKK7/MAP2K7, with genetic risk. We tested the hypothesis that Map2k7 gene haploinsufficiency in mice...

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PMID: 30691477
DOI: 10.1186/s12974-019-1408-5

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