Article
Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha.
Molecular psychiatry - 1 Nov 2010
Carroll L S, Williams N M, Moskvina V, Russell E, Norton N, Williams H J, Peirce T, Georgieva L, Dwyer S, Grozeva D, Greene E, Farmer A, McGuffin P, Morris D W, Corvin A, Gill M, Rujescu D, Sham P, Holmans P, Jones I, Kirov G, Craddock N, O'Donovan M C, Owen M J
Abstract excerpt
We earlier reported a genome-wide significant linkage to schizophrenia at chromosome 17 that was identified in a single pedigree (C702) consisting of six affected, male siblings with DSM-IV schizophrenia and prominent mood symptoms. In this study, we adopted several approaches in an attempt to map the putative disease locus. First, mapping the source of linkage to chromosome 17 in pedigree C702. We refined the...
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