Article
Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity.
Cancer cell - 14 Aug 2012
Leite de Oliveira Rodrigo, Deschoemaeker Sofie, Henze Anne-Theres, Debackere Koen, Finisguerra Veronica, Takeda Yukiji, Roncal Carmen, Dettori Daniela, Tack Evelyne, Jönsson Yannick, Veschini Lorenzo, Peeters Annelies, Anisimov Andrey, Hofmann Matthias, Alitalo Kari, Baes Myriam, D'hooge Jan, Carmeliet Peter, Mazzone Massimiliano
Abstract excerpt
The success of chemotherapy in cancer treatment is limited by scarce drug delivery to the tumor and severe side-toxicity. Prolyl hydroxylase domain protein 2 (PHD2) is an oxygen/redox-sensitive enzyme that induces cellular adaptations to stress conditions. Reduced activity of PHD2 in endothelial cells normalizes tumor vessels and enhances perfusion. Here, we show that tumor vessel normalization by genetic...
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