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Article

Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice.

Journal of hepatology - 1 Jul 2012

Heindryckx Femke, Kuchnio Anna, Casteleyn Christophe, Coulon Stephanie, Olievier Kim, Colle Isabelle, Geerts Anja, Libbrecht Louis, Carmeliet Peter, Van Vlierberghe Hans

Abstract excerpt

BACKGROUND & AIMS: The two major primary liver cancers in adults are hepatocellular carcinoma and cholangiocarcinoma. These tumors rapidly outgrow their vascular supply and become hypoxic, resulting in the production of hypoxia inducible factors. Recently, interest has grown in the regulators of these factors. Several reports have been published describing the role of prolyl hydroxylase domains--the key oxygen...

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Identifiers

PMID: 22420978
DOI: 10.1016/j.jhep.2012.02.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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