Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in toll-like receptor 4 underlie susceptibility to tumor induction by the mouse polyomavirus.

Journal of virology - 1 Nov 2012

Velupillai Palanivel, Sung Chang Kyoo, Andrews Erik, Moran Jennifer, Beier David, Kagan Jonathan, Benjamin Thomas

Abstract excerpt

PERA/Ei (PE) mice are susceptible to tumor induction by polyomavirus (Py), while C57BR/cdJ (BR) mice are resistant. Antigen-presenting cells from BR mice respond to the virus with interleukin-12 (IL-12) and those from PE mice with IL-10. These polarized cytokine responses underlie the development of effective antitumor immunity in BR mice and the lack thereof in PE mice. An ex vivo cytokine production assay using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Cytokines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasms

Share to Polymorphism, Single Nucleotide

Share to Polyomavirus

Share to Quantitative Trait Loci

Share to Toll-Like Receptor 4

Source

Open in PubMed Open full text

Identifiers

PMID: 22896604
DOI: 10.1128/JVI.01614-12
PMCID: PMC3486304

Genes

TLR4
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in toll-like receptor 4 underlie susceptibility to tumor induction by the mouse polyomavirus.PMID 22896604Read ↗

Type I Interferon production in myeloid cells is regulated by factors independent of <i>Ptpn22</i>Semantic proximity Read ↗

Susceptibility to tumors induced by polyoma virus is conferred by an endogenous mouse mammary tumor virus superantigen.Semantic proximity Read ↗

Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice.Semantic proximity Read ↗

Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response.Semantic proximity Read ↗

Analysis of lung tumorigenesis in chimeric mice indicates the Pulmonary adenoma resistance 2 (Par2) locus to operate in the tumor-initiation stage in a cell-autonomous manner: detection of polymorphisms in the Poli gene as a candidate for Par2.Semantic proximity Read ↗

Beta 2-microglobulin knockout mice are highly susceptible to polyoma virus tumorigenesis.Semantic proximity Read ↗

Host genetics of Bordetella pertussis infection in mice: significance of Toll-like receptor 4 in genetic susceptibility and pathobiology.Semantic proximity Read ↗

Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling.Semantic proximity Read ↗

The plasmacytoma resistance gene, Pctr2, delays the onset of tumorigenesis and resides in the telomeric region of chromosome 4.Semantic proximity Read ↗

Pyvs: a dominantly acting gene in C3H/BiDa mice conferring susceptibility to tumor induction by polyoma virus.Semantic proximity Read ↗

Transcription Factor SP2 Enhanced the Expression of Cd14 in Colitis-Susceptible C3H/HeJBir.Semantic proximity Read ↗

The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.