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Article

TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2012

Chen-Plotkin Alice S, Unger Travis L, Gallagher Michael D, Bill Emily, Kwong Linda K, Volpicelli-Daley Laura, Busch Johanna I, Akle Sebastian, Grossman Murray, Van Deerlin Vivianna, Trojanowski John Q, Lee Virginia M-Y

Abstract excerpt

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is a fatal neurodegenerative disease with no available treatments. Mutations in the progranulin gene (GRN) causing impaired production or secretion of progranulin are a common Mendelian cause of FTLD-TDP; additionally, common var...

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Source

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Identifiers

PMID: 22895706
DOI: 10.1523/JNEUROSCI.0521-12.2012
PMCID: PMC3446826

Genes

TMEM106B
GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22895706-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.PMID 22895706Read ↗

Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.Semantic proximity Read ↗

The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and functionSemantic proximity Read ↗

TMEM106B expression is reduced in Alzheimer’s disease brainsSemantic proximity Read ↗

What we know about TMEM106B in neurodegeneration.Semantic proximity Read ↗

Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.Semantic proximity Read ↗

Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.Semantic proximity Read ↗

Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in miceSemantic proximity Read ↗

TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers.Semantic proximity Read ↗

Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.Semantic proximity Read ↗

The TMEM106B locus and TDP-43 pathology in older persons without FTLD.Semantic proximity Read ↗

Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies.Semantic proximity Read ↗

The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.Semantic proximity Read ↗

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