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Article

The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers.

BMC neuroscience - 30 Sept 2009

Martínez Manuel Fernández, Martín Xabier Elcoroaristizabal, Alcelay Luís Galdos, Flores Jessica Castro, Valiente Juan María Uterga, Juanbeltz Begoña Indakoetxea, Beldarraín María Angeles Gómez, López Josefa Moraza, Gonzalez-Fernández María Carmen, Salazar Ana Molano, Gandarias Rocio Bereincua, Borda Sandra Inglés, Marqués Nuria Ortiz, Amillano Miryam Barandiarán, Zabaleta María Carrasco, de Pancorbo Marian M

Abstract excerpt

BACKGROUND: The aim of this study is to examine the influence of the catechol-O-methyltranferase (COMT) gene (polymorphism Val158 Met) as a risk factor for Alzheimer's disease (AD) and mild cognitive impairment of amnesic type (MCI), and its synergistic effect with the apolipoprotein E gene (APOE...

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Identifiers

PMID: 19793392
DOI: 10.1186/1471-2202-10-125
PMCID: PMC2765959

Genes

APOE
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-19793392-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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