Article
Epistasis between two HLA antigens defines a subset of individuals at a very high risk for ankylosing spondylitis.
Annals of the rheumatic diseases - 1 Jun 2013
van Gaalen Floris A, Verduijn Willem, Roelen Dave L, Böhringer Stefan, Huizinga Tom W J, van der Heijde Désirée M, Toes René E M
Abstract excerpt
OBJECTIVES: Susceptibility to spondyloarthritis (SpA) is largely genetically determined. To understand increasingly complex genetic associations, one approach is to study epistasis or genetic interactions. Several associations between HLA antigens and SpA including HLA-B27 have been reported. In this study, we investigated epistasis between common HLA class I risk antigens in ankylosing spondylitis (AS), the most...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.