Article
Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.
Nature communications - 21 May 2015
Cortes Adrian, Pulit Sara L, Leo Paul J, Pointon Jenny J, Robinson Philip C, Weisman Michael H, Ward Michael, Gensler Lianne S, Zhou Xiaodong, Garchon Henri-Jean, Chiocchia Gilles, Nossent Johannes, Lie Benedicte A, Førre Øystein, Tuomilehto Jaakko, Laiho Kari, Bradbury Linda A, Elewaut Dirk, Burgos-Vargas Ruben, Stebbings Simon, Appleton Louise, Farrah Claire, Lau Jonathan, Haroon Nigil, Mulero Juan, Blanco Francisco J, Gonzalez-Gay Miguel A, Lopez-Larrea C, Bowness Paul, Gaffney Karl, Gaston Hill, Gladman Dafna D, Rahman Proton, Maksymowych Walter P, Crusius J Bart A, van der Horst-Bruinsma Irene E, Valle-Oñate Raphael, Romero-Sánchez Consuelo, Hansen Inger Myrnes, Pimentel-Santos Fernando M, Inman Robert D, Martin Javier, Breban Maxime, Wordsworth Bryan Paul, Reveille John D, Evans David M, de Bakker Paul I W, Brown Matthew A
Abstract excerpt
Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and controls of European descent. We impute SNPs, classical HLA alleles and amino-acid residues within...
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