HLA-B*27 subtypes and their implications in the pathogenesis of ankylosing spondylitis.

doi:10.1016/j.gene.2018.05.092

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Article

HLA-B*27 subtypes and their implications in the pathogenesis of ankylosing spondylitis.

Gene - 5 Sept 2018

Dashti Navid, Mahmoudi Mahdi, Aslani Saeed, Jamshidi Ahmadreza

Abstract excerpt

Ankylosing spondylitis (AS) is a highly heritable kind of arthritis that affects the vertebral column. AS risk has been associated strongly with Human leukocyte antigen (HLA)-B*27. In fact, some HLA-B*27 subtypes have been associated with the increased disease risk, although some specific subtypes have not shown such associations. It is supposed that HLA-B*27 plays a major role in the etiopathogenesis of the...

Topics

Genetic Association Studies
Genetic Predisposition to Disease
HLA-B27 Antigen
Humans
Spondylitis, Ankylosing

Source

Open in PubMed

Identifiers

PMID: 29803000
DOI: 10.1016/j.gene.2018.05.092

Genes

ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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