Interaction between HLA-B60 and HLA-B27 as a Better Predictor of Ankylosing Spondylitis in a Taiwanese Population.

doi:10.1371/journal.pone.0137189

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Article

Interaction between HLA-B60 and HLA-B27 as a Better Predictor of Ankylosing Spondylitis in a Taiwanese Population.

PloS one - 1 Jan 2015

Wei James Cheng-Chung, Sung-Ching Henry Wong, Hsu Yu-Wen, Wen Ya-Feng, Wang Wen-Chang, Wong Ruey-Hong, Lu Hsing-Fang, Gaalen Floris A van, Chang Wei-Chiao

Abstract excerpt

OBJECTIVE: Ankylosing spondylitis (AS) is a form of chronic inflammatory spondyloarthritis (SpA) that causes pain and stiffness in spines or joints. Human leukocyte antigen B27 (HLA-B27) and B60 (HLA-B60) have been reported as major genetic risk factors of AS. In addition, rs13202464, located on major histocompatibility complex (MHC) region, showed high sensitivity (98.7%) and specificity (98.0%) for HLA-B27....

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PMID: 26469786
DOI: 10.1371/journal.pone.0137189
PMCID: PMC4607494

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