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Article

Methylenetetrahydrofolate reductase C677T and reduced folate carrier 80 G>A polymorphisms are associated with an increased risk of conotruncal heart defects.

Clinical chemistry and laboratory medicine - 4 Feb 2012

Gong Dingxu, Gu Haiyong, Zhang YuJian, Gong Jie, Nie Yu, Wang Jue, Zhang Hui, Liu Ruiping, Hu Shengshou, Zhang Hao

Abstract excerpt

BACKGROUND: Folic acid has an important role during embryologic development, particularly the development of the cardiovascular system. METHODS: We analyzed the involvement of eight polymorphisms in genes related to folic-acid metabolism, 5,10-methylenetetrahydrofolate reductase (MTHFR), methylenetetrahydrofolate dehydrogenase (MTHFD1), transcobalamin (TCN2), reduced folate carrier (RFC),...

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Share to Heart Defects, Congenital

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Single Nucleotide

Share to Reduced Folate Carrier Protein

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 22868813
DOI: 10.1515/cclm-2011-0759

Genes

MTHFR
MTHFD1
NNMT
NPPA
TCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylenetetrahydrofolate reductase C677T and reduced folate carrier 80 G>A polymorphisms are associated with an increased risk of conotruncal heart defects.PMID 22868813Read ↗

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