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Article

A parent-of-origin analysis of paternal genetic variants and increased risk of conotruncal heart defects.

American journal of medical genetics. Part A - 1 Mar 2018

Nembhard Wendy N, Tang Xinyu, Li Jingyun, MacLeod Stewart L, Levy Joseph, Schaefer Gerald B, Hobbs Charlotte A

Abstract excerpt

The association between conotruncal heart defects (CTHDs) and maternal genetic and environmental exposures is well studied. However, little is known about paternal genetic or environmental exposures and risk of CTHDs. We assessed the effect of paternal genetic variants in the folate, homocysteine, and transsulfuration pathways on risk of CTHDs in offspring. We utilized National Birth Defects Prevention Study data...

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Identifiers

PMID: 29399948
DOI: 10.1002/ajmg.a.38611
PMCID: PMC5881110

Genes

GLRX
GSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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