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Article

Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes.

American journal of medical genetics. Part A - 15 Sept 2005

Shaw Gary M, Iovannisci David M, Yang Wei, Finnell Richard H, Carmichael Suzan L, Cheng Suzanne, Lammer Edward J

Abstract excerpt

Investigating possible genetic polymorphisms and gene-environment interactions in the etiology of human conotruncal defects is a prudent research approach. In this study we explore gene-only and gene-environment effects of 32 single nucleotide polymorphisms (SNPs) on conotruncal defect risks. The genes bearing these SNPs participate in one of five pathogenetic processes, homocysteine metabolism, coagulation,...

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Source

Identifiers

PMID: 16100725
DOI: 10.1002/ajmg.a.30924

Genes

NOS3
NPPA
ADD1
ITGB3
MTHFR
TNF

Variants

Provenance

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