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Article

Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects.

Journal of biomedicine & biotechnology - 1 Jan 2010

Lupo Philip J, Goldmuntz Elizabeth, Mitchell Laura E

Abstract excerpt

Conotruncal and related heart defects (CTRD) are common, complex malformations. Although there are few established risk factors, there is evidence that genetic variation in the folate metabolic pathway influences CTRD risk. This study was undertaken to assess the association between inherited (i.e., case) and maternal gene-gene interactions in this pathway and the risk of CTRD. Case-parent triads (n = 727),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

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Identifiers

PMID: 20111745
DOI: 10.1155/2010/630940
PMCID: PMC2810479

Genes

MTHFR
CBS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects.PMID 20111745Read ↗

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