Article
Glutamate gene polymorphisms predict brain volumes in multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Mar 2013
Strijbis Eva M M, Inkster Becky, Vounou Maria, Naegelin Yvonne, Kappos Ludwig, Radue Ernst-Wilhelm, Matthews Paul M, Uitdehaag Bernard M J, Barkhof Frederik, Polman Chris H, Montana Giovanni, Geurts Jeroen J G
Abstract excerpt
BACKGROUND: Several genetic markers have been associated with multiple sclerosis (MS) susceptibility; however, uncovering the genetic aetiology of the complex phenotypic expression of MS has been more difficult so far. The most common approach in imaging genetics is based on mass-univariate linear modelling (MULM), which faces several limitations. OBJECTIVE: Here we apply a novel multivariate statistical model,...
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