Article
A Risk Score for Predicting Multiple Sclerosis.
PloS one - 1 Jan 2016
Dobson Ruth, Ramagopalan Sreeram, Topping Joanne, Smith Paul, Solanky Bhavana, Schmierer Klaus, Chard Declan, Giovannoni Gavin
Abstract excerpt
OBJECTIVE: Multiple sclerosis (MS) develops as a result of environmental influences on the genetically susceptible. Siblings of people with MS have an increased risk of both MS and demonstrating asymptomatic changes in keeping with MS. We set out to develop an MS risk score integrating both genetic and environmental risk factors. We used this score to identify siblings at extremes of MS risk and attempted to...
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