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Article

CYP7A1 polymorphism influences the LDL cholesterol-lowering response to atorvastatin.

Journal of clinical pharmacy and therapeutics - 1 Dec 2012

Jiang X-Y, Zhang Q, Chen P, Li S-Y, Zhang N-N, Chen X-D, Wang G-C, Wang H-B, Zhuang M-Q, Lu M

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: Response to the lipid-lowering effect of the statins is known to show significant inter-individual variability. Our aim was to investigate whether genetic variants of the CYP3A5 gene, CYP7A1 gene and ABCG8 gene influence the lipid-lowering response to atorvastatin. METHODS: One hundred and seven unrelated Chinese Han hypercholesterolemia patients were recruited from among the...

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Share to Atorvastatin
Share to ATP Binding Cassette Transporter, Subfamily G, Member 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol 7-alpha-Hydroxylase

Share to Cytochrome P-450 CYP3A

Share to Heptanoic Acids

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

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Source

Identifiers

PMID: 22882727
DOI: 10.1111/j.1365-2710.2012.01372.x

Genes

ABCG8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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