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Article

SLCO1B1 and ABCB1 variants synergistically influence the atorvastatin treatment response in South Indian coronary artery disease patients.

Pharmacogenomics - 1 Aug 2022

Bharath Govindaswamy, Vishnuprabu Durairaj Pandian, Preethi Loganathan, Nagappan Arumugam Suriyam, Dhianeshwaran Isravanya Ramia Thiagaraja, Bhaskar Lakkakula Vks, Swaminathan Nagarajan, Munirajan Arasambattu Kannan

Abstract excerpt

Introduction: Atorvastatin exhibits wide interindividual variability in treatment response, limiting the drug efficacy in coronary artery disease patients. Aim: To study the effect of genetic variants involved in atorvastatin transport/metabolism and correlate their lipid-lowering efficacy. Materials & methods: Genotyping was performed using 5'-hydrolysis probe method (n = 412), and the study evaluated the...

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Share to Atorvastatin
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, LDL

Share to Coronary Artery Disease

Share to Genotype

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Liver-Specific Organic Anion Transporter 1

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 35968761
DOI: 10.2217/pgs-2022-0044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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