Effect of Cytochrome P450 7A1 (CYP7A1) Polymorphism on Lipid Responses to Simvastatin Treatment.

doi:10.1097/FJC.0000000000000774

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Article

Effect of Cytochrome P450 7A1 (CYP7A1) Polymorphism on Lipid Responses to Simvastatin Treatment.

Journal of cardiovascular pharmacology - 1 Feb 2020

Liu Na, Yang Guihua, Liu Yingping, Hu Mei, Cai Yuyu, Hu Zhiying, Jia Chundi, Zhang Man

Abstract excerpt

BACKGROUND: Identifying patients with high risk of low response to statin therapy is important for optimization of lipid-lowering therapy. Cholesterol 7α-hydroxylase, a rate-limiting enzyme encoded by cytochrome P450 7A1 (CYP7A1) gene, is considered to be associated with statin efficacy. This study aimed to investigate the association between a novel CYP7A1 single nucleotide polymorphism rs3824260 and statin...

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PMID: 31663874
DOI: 10.1097/FJC.0000000000000774

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