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Article

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition.

Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2012

Wilcken Rainer, Wang GuoZhen, Boeckler Frank M, Fersht Alan R

Abstract excerpt

Aggregation of destabilized mutants of the tumor suppressor p53 is a major route for its loss of activity. In order to assay drugs that inhibit aggregation of p53, we established the basic kinetics of aggregation of its core domain, using the mutant Y220C that has a mutation-induced, druggable ca...

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Identifiers

PMID: 22869713
DOI: 10.1073/pnas.1211550109
PMCID: PMC3427094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22869713-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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