Article
Characterization of full-length p53 aggregates and their kinetics of formation.
Biophysical journal - 15 Nov 2022
Julian Linda, Sang Jason C, Wu Yunzhao, Meisl Georg, Brelstaff Jack H, Miller Alyssa, Cheetham Matthew R, Vendruscolo Michele, Knowles Tuomas P J, Ruggeri Francesco Simone, Bryant Clare, Ros Susana, Brindle Kevin M, Klenerman David
Abstract excerpt
Mutations in the TP53 gene are common in cancer with the R248Q missense mutation conferring an increased propensity to aggregate. Previous p53 aggregation studies showed that, at micromolar concentrations, protein unfolding to produce aggregation-prone species is the rate-determining step. Here we show that, at physiological concentrations, aggregation kinetics of insect cell-derived full-length wild-type p53 and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.