Article
TNFRSF11B gene polymorphisms, bone mineral density, and fractures in Slovak postmenopausal women.
Journal of applied genetics - 1 Feb 2015
Boroňová Iveta, Bernasovská Jarmila, Mačeková Soňa, Petrejčíková Eva, Tomková Zlatica, Kľoc Ján, Poráčová Janka, Blaščáková Marta Mydlárová, Litavcová Eva
Abstract excerpt
Osteoporosis is a common disease that is characterized by low bone mineral density (BMD), deterioration in bone microarchitecture, and increased fracture risk. Due to its important role in bone biology, the TNFRSF11B gene, coding for OPG, has been considered as a candidate gene for osteoporosis. In this study, single nucleotide polymorphisms (SNPs) A163G, T245G, and G1181C (rs3102735, rs3134069, and rs2073618,...
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