Article
Important gene-gene interaction of TNF-α and VDR on osteoporosis in community-dwelling elders.
PloS one - 1 Jan 2019
Liao Li-Na, Li Chia-Ing, Wu Fang-Yang, Yang Chuan-Wei, Lin Chih-Hsueh, Liu Chiu-Shong, Lin Wen-Yuan, Li Tsai-Chung, Lin Cheng-Chieh
Abstract excerpt
Gene effects on osteoporosis have been studied separately and may have been masked by gene-gene and gene-environment interactions. We evaluated gene-gene and gene-physical activity interactions of the variants of tumor necrosis factor-α (TNF-α) and vitamin D receptor (VDR) genes on osteoporosis. A total of 472 elders were included. Seven variants (TNF-α: rs1799964, rs1800629, rs3093662; VDR: rs7975232, rs1544410,...