Article
Evaluation of genetic variants in IL-1B and its interaction with the predisposition of osteoporosis in the northwestern Chinese Han population.
The journal of gene medicine - 1 Oct 2020
He Zhiyi, Sun Yao, Wu Jiamin, Xiong Zichao, Zhang Shanshan, Liu Jianfeng, Liu Yuanwei, Li Haiyue, Jin Tianbo, Yang Yonghui, Yang Shuya
Abstract excerpt
BACKGROUND: Interleukin (IL)-1β stimulates the proliferation and differentiation of osteoclast precursors into mature osteoclasts. IL-1B polymorphisms may influence the gene and protein expression of IL-1β. The present study aimed to investigate the association of IL-1B variants (rs2853550, rs1143643, rs3136558, rs1143630, rs1143627, and ) and their interaction with osteoporosis risk among the...