Article
Dietary folate and APC mutations in sporadic colorectal cancer.
The Journal of nutrition - 1 Dec 2006
de Vogel Stefan, van Engeland Manon, Lüchtenborg Margreet, de Bruïne Adriaan P, Roemen Guido M J M, Lentjes Marjolein H F M, Goldbohm R Alexandra, van den Brandt Piet A, de Goeij Anton F P M, Weijenberg Matty P
Abstract excerpt
Folate deficiency has been associated with colorectal cancer risk and may be involved in colorectal carcinogenesis through increased chromosome instability, gene mutations, and aberrant DNA methylation. Within the Netherlands Cohort Study on diet and cancer, we investigated the associations between dietary folate intake and colorectal cancer risk with (APC(+)) and without (APC(-)) truncating APC mutations,...
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