Article
Dietary heme iron and the risk of colorectal cancer with specific mutations in KRAS and APC.
Carcinogenesis - 1 Dec 2013
Gilsing Anne M J, Fransen Fiona, de Kok Theo M, Goldbohm Alexandra R, Schouten Leo J, de Bruïne Adriaan P, van Engeland Manon, van den Brandt Piet A, de Goeij Anton F P M, Weijenberg Matty P
Abstract excerpt
Red meat intake has been linked to increased colorectal cancer (CRC) risk. Although the underlying mechanisms remain unclear, experimental studies suggest a role for dietary heme iron. Because heme iron was shown to promote specific mutations, it would be insightful to link heme iron data to CRC with mutations in key genes in an observational, population-based study. We investigated the association between...
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