Article
Dietary factors and truncating APC mutations in sporadic colorectal adenomas.
International journal of cancer - 1 Jan 2005
Diergaarde Brenda, Tiemersma Edine W, Braam Hanneke, van Muijen Goos N P, Nagengast Fokko M, Kok Frans J, Kampman Ellen
Abstract excerpt
Inactivating mutations in APC are thought to be early, initiating events in colorectal carcinogenesis. To gain insight into the relationship between diet and inactivating APC mutations, we evaluated associations between dietary factors and the occurrence of these mutations in a Dutch case-control study of sporadic colorectal adenomas (278 cases; 414 polyp-free controls). Direct-sequencing was used to screen...
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