Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants.

doi:10.1093/carcin/bgn082

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Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants.

Carcinogenesis - 1 Sept 2008

Theodoratou Evropi, Campbell Harry, Tenesa Albert, McNeill Geraldine, Cetnarskyj Roseanne, Barnetson Rebecca A, Porteous Mary E, Dunlop Malcolm G, Farrington Susan M

Abstract excerpt

In a large Scottish case-control study, we investigated the effects of adenomatous polyposis coli (APC) Asp1822Val (rs459552) and APC Glu1317Gln substitutions on colorectal cancer (CRC) risk and whether these associations were influenced by lifestyle and dietary factors. We did not observe any associations between the variants and CRC risk in the whole population. Post-menopausal women taking hormone replacement...

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PMID: 18375958
DOI: 10.1093/carcin/bgn082

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