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Article

Genetic linkage analysis in the age of whole-genome sequencing.

Nature reviews. Genetics - 1 May 2015

Ott Jurg, Wang Jing, Leal Suzanne M

Abstract excerpt

For many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and complex traits with familial aggregation. Linkage analysis was largely supplanted by the wide adoption of genome-wide association studies (GWASs). However, with the recent increased use of whole-genome sequencing (WGS), linkage analysis is again emerging as an important and powerful analysis method for the...

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PMID: 25824869
DOI: 10.1038/nrg3908
PMCID: PMC4440411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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