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Article

Novel Nonsense Variants c.58C>T (p.Q20X) and c.256G>T (p.E85X) in the CHEK2 Gene Identified dentified in Breast Cancer Patients from Balochistan.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2016

Baloch Abdul Hameed, Khosa Ahmad Nawaz, Bangulzai Nasrullah, Shuja Jamila, Naseeb Hafiz Khush, Jan Mohammad, Marghazani Illahi Bakhsh, Kakar Masood-Ul-Haq, Baloch Dost Mohammad, Cheema Abdul Majeed, Ahmad Jamil

Abstract excerpt

Breast cancer is the most commonly occurring and leading cause of cancer deaths among women globally. Hereditary cases account 5-10% of all the cases and CHEK2 is considered as a moderate penetrance breast cancer risk gene. CHEK2 plays a crucial role in response to DNA damage to promote cell cycle arrest and repair DNA damage or induce apoptosis. Our objective in the current study was to analyze mutations in the...

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Identifiers

PMID: 27039729
DOI: 10.7314/apjcp.2016.17.3.1089

Genes

CHEK2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Novel Nonsense Variants c.58C>T (p.Q20X) and c.256G>T (p.E85X) in the CHEK2 Gene Identified dentified in Breast Cancer Patients from Balochistan.PMID 27039729Read ↗

Novel Nonsense Variants c.58C>T (p.Q20X) and c.256G>T (p.E85X) in the CHEK2 Gene Identified in Breast Cancer Patients from Balochistan.Semantic proximity Read ↗

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