Article
[Breeding of transgenic mice expressing human tau isoform with P301L mutation and identification of homozygous transgenic mice].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology - 1 May 2012
Wang Yan-yan, Chen Ru-zhui, Zhu Xiao-nani, Liu Jing, Li Zhi-hui, Liu Xiu-juan, Li Zhi-hui, Na Xin, Liang Shan-shan, Qiu Guo-guang, Zhang Wei, Wang Hai, Wang Xue-lan
Abstract excerpt
OBJECTIVE: To establish homozygous transgenic mouse strain expressing human tau isoform with P301L mutation. METHODS: Five transgenic mice expressing human tau isoform with P301L mutation were obtained by microinjection into male nuclei. Homozygote and hemizygote were identified by PCR and real-time fluorescent quantitative PCR. RESULTS: Ninety five homozygous transgenic mice were selected, and the results...
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