Article
A canine model of Alzheimer's disease generated by overexpressing a mutated human amyloid precursor protein.
International journal of molecular medicine - 1 Apr 2014
Lee Geun-Shik, Jeong Yeon Woo, Kim Joung Joo, Park Sun Woo, Ko Kyeong Hee, Kang Mina, Kim Yu Kyung, Jung Eui-Man, Moon Changjong, Hyun Sang Hwan, Hwang Kyu-Chan, Kim Nam-Hyung, Shin Taeyoung, Jeung Eui-Bae, Hwang Woo Suk
Abstract excerpt
Canines are considered the most authentic model for studying multifactorial human diseases, as these animals typically share a common environment with man. Somatic cell nuclear transfer (SCNT) technology along with genetic engineering of nuclear donor cells provides a unique opportunity for examining human diseases using transgenic canines. In the present study, we generated transgenic canines that overexpressed...
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