Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human TAUP301L overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain.

Scientific reports - 11 Oct 2017

Cosacak Mehmet I, Bhattarai Prabesh, Bocova Ledio, Dzewas Tim, Mashkaryan Violeta, Papadimitriou Christos, Brandt Kerstin, Hollak Heike, Antos Christopher L, Kizil Caghan

Abstract excerpt

Microtubule-associated TAU protein is a pathological hallmark in Alzheimer's disease (AD), where hyperphosphorylation of TAU generates neurofibrillary tangles. To investigate the effects of TAU in a regenerative adult vertebrate brain system, we generated a cre/lox-based transgenic model of zebrafish that chronically expresses human TAUP301L, which is a variant of human TAU protein that forms neurofibrillary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Cell Death

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutant Proteins

Share to Nerve Regeneration

Share to Neurofibrillary Tangles

Share to Proliferating Cell Nuclear Antigen

Share to Protein Multimerization

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 29021554
DOI: 10.1038/s41598-017-13311-5
PMCID: PMC5636889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human TAUP301L overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain.PMID 29021554Read ↗

Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivoSemantic proximity Read ↗

Characterization of a novel transgenic rat carrying human tau with mutation P301L.Semantic proximity Read ↗

Zebrafish as a model organism for neurodegenerative diseaseSemantic proximity Read ↗

Transgenic zebrafish model of neurodegeneration.Semantic proximity Read ↗

Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of TauopathySemantic proximity Read ↗

Non-Rodent Genetic Animal Models for Studying Tauopathy: Review of Drosophila, Zebrafish, and C. elegans ModelsSemantic proximity Read ↗

Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathySemantic proximity Read ↗

Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.Semantic proximity Read ↗

Transgenic zebrafish models of neurodegenerative diseases.Semantic proximity Read ↗

Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and Aβ1-42 gene transfer models.Semantic proximity Read ↗

Modeling Neurodegeneration in ZebrafishSemantic proximity Read ↗

Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.