Article
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.
Cell - 16 Apr 2010
Chen Hsiuchen, Vermulst Marc, Wang Yun E, Chomyn Anne, Prolla Tomas A, McCaffery J Michael, Chan David C
Abstract excerpt
Mitochondria are highly mobile and dynamic organelles that continually fuse and divide. These processes allow mitochondria to exchange contents, including mitochondrial DNA (mtDNA). Here we examine the functions of mitochondrial fusion in differentiated skeletal muscle through conditional deletion of the mitofusins Mfn1 and Mfn2, mitochondrial GTPases essential for fusion. Loss of the mitofusins causes severe...
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