Article
Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Mar 2010
Misko Albert, Jiang Sirui, Wegorzewska Iga, Milbrandt Jeffrey, Baloh Robert H
Abstract excerpt
Mitofusins (Mfn1 and Mfn2) are outer mitochondrial membrane proteins involved in regulating mitochondrial dynamics. Mutations in Mfn2 cause Charcot-Marie-Tooth disease (CMT) type 2A, an inherited disease characterized by degeneration of long peripheral axons, but the nature of this tissue selecti...
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