Article
Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels.
Chemical research in toxicology - 17 Sept 2012
Twiner Michael J, Doucette Gregory J, Rasky Andrew, Huang Xi-Ping, Roth Bryan L, Sanguinetti Michael C
Abstract excerpt
Azaspiracids (AZA) are polyether marine dinoflagellate toxins that accumulate in shellfish and represent an emerging human health risk. Although human exposure is primarily manifested by severe and protracted diarrhea, this toxin class has been shown to be highly cytotoxic, a teratogen to developing fish, and a possible carcinogen in mice. Until now, AZA's molecular target has not yet been determined. Using three...
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