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Article

Molecular analysis of the sea anemone toxin Av3 reveals selectivity to insects and demonstrates the heterogeneity of receptor site-3 on voltage-gated Na+ channels.

The Biochemical journal - 15 Aug 2007

Moran Yehu, Kahn Roy, Cohen Lior, Gur Maya, Karbat Izhar, Gordon Dalia, Gurevitz Michael

Abstract excerpt

Av3 is a short peptide toxin from the sea anemone Anemonia viridis shown to be active on crustaceans and inactive on mammals. It inhibits inactivation of Na(v)s (voltage-gated Na+ channels) like the structurally dissimilar scorpion alpha-toxins and type I sea anemone toxins that bind to receptor site-3. To examine the potency and mode of interaction of Av3 with insect Na(v)s, we established a system for its...

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Identifiers

PMID: 17492942
DOI: 10.1042/BJ20070233
PMCID: PMC1948988

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