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Article

The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels.

Biochemical and biophysical research communications - 1 Jan 2010

Ozoe Yoshihisa, Asahi Miho, Ozoe Fumiyo, Nakahira Kunimitsu, Mita Takeshi

Abstract excerpt

A structurally unique isoxazoline class compound, A1443, exhibits antiparasitic activity against cat fleas and dog ticks comparable to that of the commercial ectoparasiticide fipronil. This isoxazoline compound inhibits specific binding of the gamma-aminobutyric acid (GABA) receptor channel blocker [(3)H]4'-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) to housefly-head membranes, with an IC(50) value of 455pM. In...

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PMID: 19944072
DOI: 10.1016/j.bbrc.2009.11.131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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