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Article

Functional Validation of the Phase I-II-III Detoxification Pathway in Azumapecten farreri using Optimized RNA Interference Technology.

Marine biotechnology (New York, N.Y.) - 2 Sept 2026

Lu Limin, Zheng Guanchao, Lin Yichen, Dong Chenfan, Peng Jixing, Wu Haiyan, Tan Zhijun

Abstract excerpt

Paralytic shellfish toxins (PSTs) are widely distributed neurotoxins that accumulate and transform in bivalves, but the metabolic mechanisms after exposure of Azumapecten farreri (A. farreri) to PSTs remain unknown. To verify the phase I (cytochrome P450, CYP450)-II (glutathione S-transferase, GST)-III (ABC transport) metabolic genes for PSTs, we used RNA interference (RNAi) to silence target genes (CYP46A1,...

Read the complete abstract on PubMed

Topics

Animals
RNA Interference
Polymorphism, Single Nucleotide
Marine Toxins
Pectinidae
Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

RNA, Small Interfering

Glutathione Transferase

Source

Identifiers

PMID: 42684466
DOI: 10.1007/s10126-026-10698-z

Genes

CYP46A1
ABCF2
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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